Apixaban for treatment of venous thromboembolism (VTEtx): Use of MBMA to support Phase 3 dose selection and beyond Publication Apixaban for treatment of venous thromboembolism (VTEtx): Use of MBMA to support Phase 3 dose selection and beyond Apixaban is an orally available, direct, selective inhibitor of the coagulation factor Xa that reversibly…Jieun Choe2018 年 6 月 2 日
Model-informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor Publication Model-informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor Danielle Pillsbury2018 年 2 月 15 日
Drug Asset Evaluation: Increasing “Probability of Success” of a Deal White Paper 药物资产评估:提高交易的 "成功概率” Certara’s due diligence/asset evaluation teams are comprised of drug development and commercialization experts who advise…Danielle Pillsbury2017 年 8 月 24 日
Model-based Meta-analysis: An Innovative Methodology Comes of Age White Paper 基于模型的荟萃分析(MBMA):创新方法的时代来临了 MBMA integrates internal and external drug development data to inform proprietary commercial and R&D decisions.…Danielle Pillsbury2016 年 7 月 14 日
Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis Publication Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis The objective of this study was to assess the relationship between short-term and long-term treatment…Danielle Pillsbury2016 年 7 月 1 日
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Publication Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…Danielle Pillsbury2015 年 5 月 1 日
A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma Publication A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma PURPOSE: To characterize dose and response for intraocular pressure (IOP) reduction and incidence of hyperemia…Danielle Pillsbury2015 年 5 月 1 日
Time Course of Bone Mineral Density Changes with Denosumab Compared with Other Drugs in Postmenopausal Osteoporosis: A Dose-response-based Meta-analysis Publication Time Course of Bone Mineral Density Changes with Denosumab Compared with Other Drugs in Postmenopausal Osteoporosis: A Dose-response-based Meta-analysis Our objective was to compare the time course of bone mineral density (BMD) changes at…Danielle Pillsbury2014 年 10 月 1 日
Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients Publication Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…Danielle Pillsbury2014 年 5 月 21 日
A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain Publication A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain Pain is a major symptom in many medical conditions which can be relieved thanks to…Danielle Pillsbury2014 年 2 月 13 日