The article “Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator” by Kilford et al. outlines a framework for qualifying the Simcyp Simulator to predict CYP-mediated drug-drug interactions (DDIs). By using a DDI matrix, the study evaluated competitive and mechanism-based inhibition across several CYP enzymes, showing strong predictive accuracy. This work supports the Simcyp Simulator’s application in regulatory submissions for assessing DDI risks in drug development.

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