Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-drug Interactions Publication Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-drug Interactions The magnitude of any metabolic drug-drug interactions (DDIs) depends on fractional importance of inhibited pathway…Danielle Pillsbury2013 年 5 月 30 日
The Future of the Pharmaceutical Sciences and Graduate Education: Recommendations from the AACP Graduate Education Special Interest Group Publication The Future of the Pharmaceutical Sciences and Graduate Education: Recommendations from the AACP Graduate Education Special Interest Group Despite pharma's recent sea change in approach to drug discovery and development, U.S. pharmaceutical sciences…Danielle Pillsbury2013 年 5 月 13 日
Investigation of the Role of Fc-γ-R and FcRn in mAb Distribution to the Brain Publication Investigation of the Role of Fc-γ-R and FcRn in mAb Distribution to the Brain To evaluate the role of Fc receptors (FcR) on IgG distribution to the brain, the disposition of 8C2, a murine…Danielle Pillsbury2013 年 5 月 6 日
Biodistribution and Pharmacokinetics of EGFR-targeted Thiolated Gelatin Nanoparticles Following Systemic Administration in Pancreatic Tumor-bearing Mice Publication Biodistribution and Pharmacokinetics of EGFR-targeted Thiolated Gelatin Nanoparticles Following Systemic Administration in Pancreatic Tumor-bearing Mice The objective of this study was to evaluate qualitative and quantitative biodistribution of epidermal growth…Danielle Pillsbury2013 年 5 月 6 日
Synergistic Interactions between Sorafenib and Everolimus in Pancreatic Cancer Xenografts in Mice Publication Synergistic Interactions between Sorafenib and Everolimus in Pancreatic Cancer Xenografts in Mice Molecular targeting of cellular signaling pathways is a promising approach in cancer therapy, but often…Danielle Pillsbury2013 年 5 月 1 日
Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Mice Publication Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Mice Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved as an immunosuppressant and for…Danielle Pillsbury2013 年 5 月 1 日
Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses Publication Brain Extracellular γ-hydroxybutyrate Concentrations are Decreased by L-lactate in Rats: Role in the Treatment of Overdoses L-lactate represents a potential treatment for GHB overdose by inhibiting GHB renal reabsorption mediated by…Danielle Pillsbury2013 年 5 月 1 日
Do Children Have the Same Vulnerability to Metabolic Drug-drug Interactions as Adults? A Critical Analysis of the Literature Publication Do Children Have the Same Vulnerability to Metabolic Drug-drug Interactions as Adults? A Critical Analysis of the Literature Many drug–drug interactions (DDIs) in the pediatric population are managed based on data generated in…Danielle Pillsbury2013 年 5 月 1 日