Therapeutic Specialties Archives

Blog

开发靶向共价抑制剂药物：3关键考虑因素

Traditional mechanisms of drug action rely on the reversible, noncovalent interaction of a ligand with…

Certara2021 年 11 月 5 日

Press Release

Certara Simcyp™ 新冠肺炎疫苗模型获R&D 100 奖

Biosimulation tool to conduct ‘what-if’ scenarios with virtual patients recognized in Software/Services category PRINCETON, NJ…

Certara2021 年 10 月 25 日

Blog

利用 Simcyp PBPK 加快 ADC 的开发进程

With nearly 10 million deaths in 2020 and despite great progress, cancer remains the leading…

Certara2021 年 10 月 15 日

Case Study

使用 Simcyp Simulator 确定 Guanfacine 在儿童中的药物相互作用风险

Guanfacine (Intuniv® XR) extended release (GXR) is an orally administered, selective alpha2A-adrenergic receptor agonist, non-stimulant…

Certara2021 年 8 月 26 日

Case Study

Using a PBPK-PD Receptor Occupancy Model to Determine the Optimal Dose of Radiprodil for Neonates

Radiprodil is a selective allosteric modulator of the NR2B N-methyl-D-aspartate receptor GluN2B-NMDA that was being…

Certara2021 年 8 月 26 日

Case Study

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Quetiapine is an atypical antipsychotic for treating schizophrenia, bipolar depression, bipolar mania that helps to…

Certara2021 年 8 月 26 日

Case Study

Simcyp 年龄定义功能助力优化新生儿 Everolimus 给药方案

Everolimus (Afinitor®) was recently approved as adjunctive therapy for tuberous sclerosis complex (TSC)-associated partial seizures…

Certara2021 年 8 月 26 日

Case Study

Eliglustat for Gaucher Disease: Quantifying the Impact of Pharmacogenetic Status on DDIs

In 2014, Eliglustat (Cerdelga®) was approved by the FDA as the first long-term treatment for…

Certara2021 年 8 月 26 日

Case Study

Using PBPK for Label Recommendations in Rare Disease: Deflazacort for Duchenne Muscular Dystrophy

Certara2021 年 8 月 20 日

Case Study

Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification

Aripiprazole lauroxil (Aristada®) was approved by the FDA for treating schizophrenia in adults in October…

Certara2021 年 8 月 12 日

治疗领域

开发靶向共价抑制剂药物：3关键考虑因素

Certara Simcyp™ 新冠肺炎疫苗模型获R&D 100 奖

利用 Simcyp PBPK 加快 ADC 的开发进程

使用 Simcyp Simulator 确定 Guanfacine 在儿童中的药物相互作用风险

Using a PBPK-PD Receptor Occupancy Model to Determine the Optimal Dose of Radiprodil for Neonates

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Simcyp 年龄定义功能助力优化新生儿 Everolimus 给药方案

Eliglustat for Gaucher Disease: Quantifying the Impact of Pharmacogenetic Status on DDIs

Using PBPK for Label Recommendations in Rare Disease: Deflazacort for Duchenne Muscular Dystrophy

Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification

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