Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 Publication Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…Certara2015 年 3 月 31 日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Publication Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…Certara2015 年 2 月 15 日
Study Reanalysis Using a Mechanism-based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes Publication Study Reanalysis Using a Mechanism-based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes This report describes a pharmacokinetic/pharmacodynamic model for pramlintide, an amylinomimetic, in type 1 diabetes mellitus…Certara2015 年 1 月 1 日
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors Publication The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…Certara2015 年 1 月 1 日
Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures Publication Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an…Certara2015 年 1 月 1 日
Onartuzumab with or without Bevacizumab in Combination with Weekly Paclitaxel Does Not Prolong QTc or Adversely Affect Other ECG Parameters in Patients with Locally Recurrent or Metastatic Triple-negative Breast Cancer Publication Onartuzumab with or without Bevacizumab in Combination with Weekly Paclitaxel Does Not Prolong QTc or Adversely Affect Other ECG Parameters in Patients with Locally Recurrent or Metastatic Triple-negative Breast Cancer The purpose of this study was to examine the potential effect of onartuzumab, when administered…Certara2014 年 12 月 17 日
Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates Publication Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates Meropenem is frequently prescribed in children receiving continuous renal replacement therapy (CRRT). Fluid overload is…Certara2014 年 12 月 1 日
Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis Publication Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures…Certara2014 年 12 月 1 日
Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms Publication Population Pharmacokinetics Analysis of Vigabatrin in Adults and Children with Epilepsy and Children with Infantile Spasms Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase. The purpose of these analyses was to…Certara2014 年 11 月 1 日
Development of Physiologically-based Pharmacokinetic Model to Evaluate the Relative Systemic Exposure to Quetiapine After Administration of IR and XR Formulations to Adults, Children, and Adolescents Publication Development of Physiologically-based Pharmacokinetic Model to Evaluate the Relative Systemic Exposure to Quetiapine After Administration of IR and XR Formulations to Adults, Children, and Adolescents Quetiapine is an atypical antipsychotic drug with a high permeability, moderate solubility and defined as…Certara2014 年 9 月 1 日