Precision Criteria to Derive Sample Size When Designing Pediatric Pharmacokinetics Studies: Which Measure of Variability Should be Used? 刊物 Precision Criteria to Derive Sample Size When Designing Pediatric Pharmacokinetics Studies: Which Measure of Variability Should be Used? A new approach for calculation of sample size in pediatric clinical pharmacokinetic studies was suggested based on desired precision for a pharmacokinetic parameter…webdev2014 年 3 月 1 日
Population Pharmacokinetic Analysis of Axitinib in Healthy Volunteers Publication Population Pharmacokinetic Analysis of Axitinib in Healthy Volunteers Axitinib is a potent and selective second generation inhibitor of vascular endothelial growth factor receptors…webdev2014 年 2 月 21 日
A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain Publication A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain Pain is a major symptom in many medical conditions which can be relieved thanks to…webdev2014 年 2 月 13 日
A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain Publication A Systems Pharmacology Perspective on the Clinical Development of Fatty Acid Amide Hydrolase Inhibitors for Pain The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase (FAAH). In…webdev2014 年 1 月 15 日
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment Publication An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…webdev2013 年 12 月 1 日
Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel Publication Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel Pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined…webdev2013 年 11 月 24 日
Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients Publication Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients The aim of this study was to assess the cardiovascular effects of a new inhaled…webdev2013 年 11 月 1 日
Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Publication Prediction of Overall Survival or Progression Free Survival by Disease Control Rate at Week 8 Is Independent of Ethnicity: Western Versus Chinese Patients with First-line Non-small Cell Lung Cancer Treated with Chemotherapy with or without Bevacizumab Categorizations of best response observed at week 8 of first-line treatment in two studies of…webdev2013 年 10 月 22 日
Differential Pharmacokinetics of Ganitumab in Patients with Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers Publication Differential Pharmacokinetics of Ganitumab in Patients with Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers Ganitumab is an investigational, fully human monoclonal antibody antagonist of the insulin-like growth factor-1 receptor…webdev2013 年 10 月 1 日
Exposure-response Analysis of Pertuzumab in HER2-positive Metastatic Breast Cancer: Absence of Effect on QTc Prolongation and Other ECG Parameters Publication Exposure-response Analysis of Pertuzumab in HER2-positive Metastatic Breast Cancer: Absence of Effect on QTc Prolongation and Other ECG Parameters The phase III trial of pertuzumab plus trastuzumab plus docetaxel versus placebo plus trastuzumab plus…webdev2013 年 9 月 3 日