Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis
Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…
Certara2015 年 5 月 1 日
Pediatric Drug Dosing: Tackling Big Problems for Little Patients
儿科药物开发的挑战与复杂性已广为人知。Pharmacometric modeling and simulation (M&S)…
Certara2015 年 4 月 23 日
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9
RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…
Certara2015 年 3 月 31 日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…
Certara2015 年 2 月 15 日
Study Reanalysis Using a Mechanism-based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes
This report describes a pharmacokinetic/pharmacodynamic model for pramlintide, an amylinomimetic, in type 1 diabetes mellitus…
Certara2015 年 1 月 1 日
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors
Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…
Certara2015 年 1 月 1 日
Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures
Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an…
Certara2015 年 1 月 1 日
Onartuzumab with or without Bevacizumab in Combination with Weekly Paclitaxel Does Not Prolong QTc or Adversely Affect Other ECG Parameters in Patients with Locally Recurrent or Metastatic Triple-negative Breast Cancer
The purpose of this study was to examine the potential effect of onartuzumab, when administered…
Certara2014 年 12 月 17 日
Meropenem in Children Receiving Continuous Renal Replacement Therapy: Clinical Trial Simulations Using Realistic Covariates
Meropenem is frequently prescribed in children receiving continuous renal replacement therapy (CRRT). Fluid overload is…
Certara2014 年 12 月 1 日
Vigabatrin Pediatric Dosing Information for Refractory Complex Partial Seizures: Results from a Population Dose-response Analysis
We predicted vigabatrin dosages for adjunctive therapy for pediatric patients with refractory complex partial seizures…
Certara2014 年 12 月 1 日
