Physiologically-based Mechanistic Modeling to Predict Complex Drug–drug Interactions Involving Simultaneous Competitive and Time-dependent Enzyme Inhibition by Parent Compound and Its Metabolite in Both Liver and Gut—The Effect of Diltiazem on the Time-course of Exposure to Triazolam
The aim of this study was to predict the magnitude of metabolic drug-drug interaction (mDDI)…
Certara2010 年 3 月 18 日
