How to Optimize Your Drug Label Using Modeling and Simulation Technology
As a trained pharmacist and scientist, I think a lot about patient care and how…
Certara2015 年 9 月 29 日
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
Certara2015 年 7 月 28 日
How to Revamp Your Approach to Conventional IVIVC Models
An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…
Certara2015 年 7 月 21 日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux
A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin…
Danielle Pillsbury2013 年 9 月 1 日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part II—Prediction of P-glycoprotein Mediated Drug-drug Interactions with Digoxin
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo.…
Danielle Pillsbury2013 年 9 月 1 日
Application of In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-based Pharmacokinetic Modeling to Investigate the Impact of the CYP2C8 Polymorphism on Rosiglitazone Exposure
The purpose of this study was to predict the impact of the CYP2C8*3 genotype on…
Danielle Pillsbury2013 年 6 月 1 日
Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Mice
Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved as an immunosuppressant and for…
Danielle Pillsbury2013 年 5 月 1 日
A Physiologically-based Pharmacokinetic Modeling Approach to Predict Disease-drug Interactions: Suppression of CYP3A by IL-6
Elevated cytokine levels are known to downregulate expression and suppress activity of cytochrome P450 enzymes…
Danielle Pillsbury2013 年 4 月 10 日
Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach
The development of in vitro-in vivo extrapolation (IVIVE), a 'bottom-up' approach, to predict pharmacokinetic parameters…
Danielle Pillsbury2013 年 3 月 1 日
Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies
Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the…
Danielle Pillsbury2013 年 2 月 1 日
