pre-update Archives

Publication

Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation

A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…

Certara2005 年 9 月 1 日

Publication

Modelling Approaches to Dose Estimation in Children

Most of the drugs on the market are originally developed for adults and dosage selection…

Certara2005 年 6 月 1 日

Publication

Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity

It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…

Certara2005 年 4 月 1 日

Publication

Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials

Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…

Certara2005 年 1 月 1 日

Publication

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…

Certara2005 年 1 月 1 日

Publication

Pharmacokinetics of Dibutylphthalate in Pregnant Rats

Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late…

Certara2004 年 12 月 1 日

Publication

In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions

Recently, metabolic drug-drug interactions (M-DDI) have raised some high-profile problems in drug development resulting in restricted use, withdrawal…

Certara2004 年 12 月 1 日

Publication

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH

Drug/metabolite ratios (MRs) are used as in vivo markers of enzyme activity. The ratios are…

Certara2004 年 12 月 1 日

Publication

Predicting the Clearance of CYP2C9 Substrates

Recently, Andersson et al. (2004) reported that quantitative predictions of hepatic clearance from in vitro…

Certara2004 年 12 月 1 日

Publication

Cytochrome P450 3A Expression and Activity in the Human Small Intestine

Recently, von Richter et al measured the content of cytochrome P450 (CYP) 3A in paired…

Certara2004 年 10 月 1 日

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pre-update

Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation

Modelling Approaches to Dose Estimation in Children

Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity

Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

Pharmacokinetics of Dibutylphthalate in Pregnant Rats

In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH

Predicting the Clearance of CYP2C9 Substrates

Cytochrome P450 3A Expression and Activity in the Human Small Intestine

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