pre-update Archives

Publication

A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor

CggR belongs to the SorC family of bacterial transcriptional regulators which control the expression of…

Danielle Pillsbury2008 年 6 月 1 日

Publication

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…

Danielle Pillsbury2008 年 6 月 1 日

Publication

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Unbound IC50 (IC50,u) values of 15 drugs were determined in eight recombinantly expressed human cytochromes P450…

Danielle Pillsbury2008 年 6 月 1 日

Publication

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs…

Danielle Pillsbury2008 年 5 月 1 日

Publication

Development of CYP2D6 and CYP3A4 in the First Year of Life

Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…

Danielle Pillsbury2008 年 5 月 1 日

Publication

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…

Danielle Pillsbury2008 年 4 月 30 日

Publication

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

BACKGROUND: Erlotinib is an orally active antitumor agent. Analyses in vitro using human liver microsomes and…

Danielle Pillsbury2008 年 1 月 1 日

Publication

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In adapting to the challenge to make more informed selection of compounds for development, the…

Danielle Pillsbury2007 年 12 月 1 日

Publication

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly…

Danielle Pillsbury2007 年 11 月 1 日

Publication

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…

Danielle Pillsbury2007 年 10 月 1 日

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pre-update

A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor

In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions

Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions

Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction

Development of CYP2D6 and CYP3A4 in the First Year of Life

CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene

The Effects of CYP3A4 Inhibition on Erlotinib Pharmacokinetics: Computer-based Simulation (Simcyp) Predicts In Vivo Metabolic Inhibition

Physiologically-based Approaches Towards the Prediction of Pharmacokinetics: In Vitro-In Vivo Extrapolation

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

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