Integrating Systems Approaches into Pharmaceutical Sciences
During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and…
Certara2008 年 9 月 2 日
Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability
This is a summary report of the EUFEPS & COST B25 conference on Bioavailability and…
Certara2008 年 8 月 1 日
A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally
BACKGROUND: The spleen tyrosine kinase (Syk) is recognized as a potential pharmaceutical target for the…
Certara2008 年 7 月 1 日
Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease
The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…
Certara2008 年 7 月 1 日
Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain
The aim of this study was to develop a pain relief model for a cyclooxygenase…
Certara2008 年 7 月 1 日
A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor
CggR belongs to the SorC family of bacterial transcriptional regulators which control the expression of…
Certara2008 年 6 月 1 日
In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and Their Utility for Predicting Drug-drug Interactions
It is widely accepted that today's practice of polypharmacy inevitably increases the incidence of drug-drug…
Certara2008 年 6 月 1 日
Integrated In Vitro Analysis for the In Vivo Prediction of Cytochrome P450-mediated Drug-drug Interactions
Unbound IC50 (IC50,u) values of 15 drugs were determined in eight recombinantly expressed human cytochromes P450…
Certara2008 年 6 月 1 日
Application of CYP3A4 In Vitro Data to Predict Clinical Drug-drug Interactions: Predictions of Compounds as Objects of Interaction
Numerous retrospective analyses have shown the utility of in vitro systems for predicting potential drug-drug interactions (DDIs). Prediction of DDIs…
Certara2008 年 5 月 1 日
Development of CYP2D6 and CYP3A4 in the First Year of Life
Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…
Certara2008 年 5 月 1 日
