Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Publication Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…Danielle Pillsbury2011 年 2 月 1 日
Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery Publication Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery A combination of general anesthesia (GA) with thoracic epidural anesthesia (TEA) may have a beneficial…Danielle Pillsbury2011 年 2 月 1 日
Relationship Between AUC and Volume of Distribution Knowledge Base Relationship Between AUC and Volume of Distribution A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…Nathan Teuscher2011 年 1 月 26 日
Generics and Bioequivalence Knowledge Base Generics and Bioequivalence As the debate about health care in the United States continues forward, the term “generic…Nathan Teuscher2011 年 1 月 10 日
What are Drug-drug Interactions Anyway? 知识库 What are Drug-drug Interactions Anyway? A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…Nathan Teuscher2011 年 1 月 5 日
Assessment of Algorithms for Predicting Drug-drug Interactions Via Inhibition Mechanisms: Comparison of Dynamic and Static Models Publication Assessment of Algorithms for Predicting Drug-drug Interactions Via Inhibition Mechanisms: Comparison of Dynamic and Static Models The prediction of drug-drug interactions (DDIs) from in vitro data usually utilizes an average dosing…Danielle Pillsbury2011 年 1 月 1 日
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain Publication The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…Danielle Pillsbury2011 年 1 月 1 日
Absorption Rate Knowledge Base Absorption Rate The rate at which a drug enters the body after administration is called the absorption…Nathan Teuscher2010 年 12 月 30 日
PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals Publication PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and…Danielle Pillsbury2010 年 12 月 30 日
What is a Half-life? 知识库 What is a Half-life? One of the most incorrectly used but most often quoted parameters is half life. The…Nathan Teuscher2010 年 12 月 20 日