pre-update Archives

Publication

Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides

Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…

Danielle Pillsbury2011 年 2 月 1 日

Publication

Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery

A combination of general anesthesia (GA) with thoracic epidural anesthesia (TEA) may have a beneficial…

Danielle Pillsbury2011 年 2 月 1 日

Knowledge Base

Relationship Between AUC and Volume of Distribution

A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…

Nathan Teuscher2011 年 1 月 26 日

Knowledge Base

Generics and Bioequivalence

As the debate about health care in the United States continues forward, the term “generic…

Nathan Teuscher2011 年 1 月 10 日

知识库

What are Drug-drug Interactions Anyway?

A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…

Nathan Teuscher2011 年 1 月 5 日

Publication

Assessment of Algorithms for Predicting Drug-drug Interactions Via Inhibition Mechanisms: Comparison of Dynamic and Static Models

The prediction of drug-drug interactions (DDIs) from in vitro data usually utilizes an average dosing…

Danielle Pillsbury2011 年 1 月 1 日

Publication

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…

Danielle Pillsbury2011 年 1 月 1 日

Knowledge Base

Absorption Rate

The rate at which a drug enters the body after administration is called the absorption…

Nathan Teuscher2010 年 12 月 30 日

Publication

PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals

Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and…

Danielle Pillsbury2010 年 12 月 30 日

知识库

What is a Half-life?

One of the most incorrectly used but most often quoted parameters is half life. The…

Nathan Teuscher2010 年 12 月 20 日

pre-update

Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides

Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery

Relationship Between AUC and Volume of Distribution

Generics and Bioequivalence

What are Drug-drug Interactions Anyway?

Assessment of Algorithms for Predicting Drug-drug Interactions Via Inhibition Mechanisms: Comparison of Dynamic and Static Models

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

Absorption Rate

PBPK Modeling of Inter-individual Variability in the Pharmacokinetics of Environmental Chemicals

What is a Half-life?

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