Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450
Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However,…
Certara2011 年 3 月 1 日
Casopitant: In Vitro Data and Simcyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4
has previously been shown to be a potent and selective antagonist of the human neurokinin-1…
Certara2011 年 3 月 1 日
Modeling and Predicting Drug Pharmacokinetics in Patients with Renal Impairment
Current guidance issued by the US FDA to assess the impact of renal impairment on…
Certara2011 年 3 月 1 日
Resurgence in the Use of Physiologically-based Pharmacokinetic Models in Pediatric Clinical Pharmacology: Parallel Shift in Incorporating the Knowledge of Biological Elements and Increased Applicability to Drug Development and Clinical Practice
This study had two primary aims: (i) To describe an example of the development work…
Certara2011 年 3 月 1 日
Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
Certara2011 年 2 月 10 日
What are Direct and Indirect Pharmacodynamic Models?
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…
Certara2011 年 2 月 8 日
What is Modeling and Simulation?
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…
Certara2011 年 2 月 1 日
Physiologically-based Pharmacokinetic Model for Topotecan in Mice
Topotecan is a chemotherapeutic agent of choice for the second-line treatment of recurrent ovarian cancer.…
Certara2011 年 2 月 1 日
Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by Use of a Stable Isotope in Patients with Epilepsy
The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been…
Certara2011 年 2 月 1 日
