pre-update Archives

Publication

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived…

Danielle Pillsbury2012 年 8 月 23 日

Publication

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

The high rate of attrition during drug development and its associated high research and development…

Danielle Pillsbury2012 年 8 月 1 日

Publication

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma…

Danielle Pillsbury2012 年 8 月 1 日

Publication

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats

Increased expression of inducible nitric oxide synthase (iNOS) resulting in nitric oxide elevation represents an…

Danielle Pillsbury2012 年 8 月 1 日

Publication

γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose

Overdose of & γ;-hydroxybutyrate (GHB) frequently causes respiratory depression, occasionally resulting in death; however, little…

Danielle Pillsbury2012 年 8 月 1 日

Publication

Impact of Low-dose Ritonavir on Danoprevir Pharmacokinetics: Results of Computer-based Simulations and a Clinical Drug-drug Interaction Study

Danoprevir, a potent, selective inhibitor of the hepatitis C virus (HCV) NS3/4A protease, is metabolized…

Danielle Pillsbury2012 年 7 月 1 日

Publication

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter

Vernakalant hydrochloride is a novel, predominantly atrial-selective antiarrhythmic drug that effectively and rapidly terminates atrial…

Danielle Pillsbury2012 年 7 月 1 日

Publication

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

Sex differences in the clearance of substrates of Cytochrome P4503A (CYP3A4) have been reported frequently…

Danielle Pillsbury2012 年 7 月 1 日

Publication

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings

The physiological changes that occur in the maternal body and the placental-foetal unit during pregnancy…

Danielle Pillsbury2012 年 7 月 1 日

Publication

Prediction of Concentration-time Profile and Its Inter-individual Variability Following the Dermal Drug Absorption

Estimation of systemic exposure after absorption of any xenobiotic from the skin is very important…

Danielle Pillsbury2012 年 7 月 1 日

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pre-update

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

Saliva Versus Plasma Pharmacokinetics, Theory and Application of a Salivary Excretion Classification System

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats

γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose

Impact of Low-dose Ritonavir on Danoprevir Pharmacokinetics: Results of Computer-based Simulations and a Clinical Drug-drug Interaction Study

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings

Prediction of Concentration-time Profile and Its Inter-individual Variability Following the Dermal Drug Absorption

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