Publication

Estimating Toxicity-related Biological Pathway Altering Doses for High-throughput Chemical Risk Assessment

We describe a framework for estimating the human dose at which a chemical significantly alters…

Certara2011 年 4 月 18 日

Publication

Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients

TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of…

Certara2011 年 4 月 12 日

Publication

In Silico Prediction of Efavirenz and Rifampicin Drug-drug Interaction Considering Weight and CYP2B6 Phenotype

This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data…

Certara2011 年 4 月 1 日

Publication

Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly

Physicians committed to the care of elderly patients are challenged with the diagnosis of venous…

Certara2011 年 4 月 1 日

Publication

Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model

Prediction of metabolic clearance in extreme individuals rather than the 'average human' is becoming an…

Certara2011 年 3 月 24 日

知识库

Is a Monte Carlo Simulation an Exotic Drink?

The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…

Certara2011 年 3 月 21 日

知识库

个体 PK 和群体 PK 有什么区别？

药代动力学分析通常分为两个领域...... "PK "和 "群体 PK"。Sometimes the…

Certara2011 年 3 月 14 日

Publication

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However,…

Certara2011 年 3 月 1 日

Publication

Casopitant: In Vitro Data and Simcyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4

has previously been shown to be a potent and selective antagonist of the human neurokinin-1…

Certara2011 年 3 月 1 日

Publication

Modeling and Predicting Drug Pharmacokinetics in Patients with Renal Impairment

Current guidance issued by the US FDA to assess the impact of renal impairment on…

Certara2011 年 3 月 1 日

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Estimating Toxicity-related Biological Pathway Altering Doses for High-throughput Chemical Risk Assessment

Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients

In Silico Prediction of Efavirenz and Rifampicin Drug-drug Interaction Considering Weight and CYP2B6 Phenotype

Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly

Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model

Is a Monte Carlo Simulation an Exotic Drink?

个体 PK 和群体 PK 有什么区别？

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

Casopitant: In Vitro Data and Simcyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4

Modeling and Predicting Drug Pharmacokinetics in Patients with Renal Impairment

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