pre-update Archives

Publication

Noninvasive Real-time Fluorescence Imaging of the Lymphatic Uptake of BSA-IRDye 680 Conjugate Administered Subcutaneously in Mice

The goal of our studies was to determine lymphatic uptake of bovine serum albumin (BSA)…

Certara2012 年 5 月 1 日

Publication

Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation

Edoxaban is a novel, orally available, highly specific direct inhibitor of factor Xa and is…

Certara2012 年 5 月 1 日

Publication

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis

The purpose of this study was to compare placebo responses in neuropathic pain syndromes through systematic…

Certara2012 年 4 月 1 日

Publication

PEGylation of a Factor VIII-phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice

Hemophilia A is an X-linked bleeding disorder caused by the deficiency of factor VIII (FVIII).…

Certara2012 年 3 月 1 日

Publication

Screening of Chemicals for Human Bioaccumulative Potential with a Physiologically-based Toxicokinetic Model

Human bioaccumulative potential is an important element in the risk assessment of chemicals. Due to…

Certara2012 年 3 月 1 日

Publication

From Pre-clinical to Human—Prediction of Oral Absorption and Drug-drug Interaction Potential Using Physiologically-based Pharmacokinetic (PBPK) Modeling Approach in an Industrial Setting: A Workflow by Using Case Example

A case example is presented in which the physiologically based modeling approach has been used…

Certara2012 年 3 月 1 日

Publication

Use of a Multistaged Time-dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-drug Interaction Potential

In early discovery, compounds are often eliminated because of their potential to undergo metabolic activation…

Certara2012 年 3 月 1 日

刊物

Physiologically-based PharmacoKinetic (PBPK) Modeling Tools: How to Fit with Our Needs?

In 2005, a survey compared a number of commercial PBPK software available at the time,…

Certara2012 年 3 月 1 日

Publication

Application of IVIVE and PBPK Modeling in Prospective Prediction of Clinical Pharmacokinetics: Strategy and Approach During the Drug Discovery Phase with Four Case Studies

Prospective simulations of human pharmacokinetic (PK) parameters and plasma concentration-time curves using in vitro in…

Certara2012 年 3 月 1 日

Publication

Using Simcyp to Project Human Oral Pharmacokinetic Variability in Early Drug Research to Mitigate Mechanism-based Adverse Events

Positive allosteric modulators ('potentiators') of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) have been shown to display…

Certara2012 年 3 月 1 日

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pre-update

Noninvasive Real-time Fluorescence Imaging of the Lymphatic Uptake of BSA-IRDye 680 Conjugate Administered Subcutaneously in Mice

Modeling and Simulation of Edoxaban Exposure and Response Relationships in Patients with Atrial Fibrillation

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis

PEGylation of a Factor VIII-phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice

Screening of Chemicals for Human Bioaccumulative Potential with a Physiologically-based Toxicokinetic Model

From Pre-clinical to Human—Prediction of Oral Absorption and Drug-drug Interaction Potential Using Physiologically-based Pharmacokinetic (PBPK) Modeling Approach in an Industrial Setting: A Workflow by Using Case Example

Use of a Multistaged Time-dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-drug Interaction Potential

Physiologically-based PharmacoKinetic (PBPK) Modeling Tools: How to Fit with Our Needs?

Application of IVIVE and PBPK Modeling in Prospective Prediction of Clinical Pharmacokinetics: Strategy and Approach During the Drug Discovery Phase with Four Case Studies

Using Simcyp to Project Human Oral Pharmacokinetic Variability in Early Drug Research to Mitigate Mechanism-based Adverse Events

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