Simplifying Deconvolution
Deconvolution is used to evaluate the absorption kinetics of a drug. Unfortunately the term can…
Nathan Teuscher2014 年 1 月 13 日
The IQ-CSRC Prospective Clinical Phase 1 Study: Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?
A collaboration between the Consortium for Innovation and Quality in Pharmaceutical Development and the Cardiac…
Danielle Pillsbury2014 年 1 月 1 日
Incorporating Target Shedding into a Minimal PBPK-TMDD Model for Monoclonal Antibodies
Shedding of a pharmacological target from cells, giving rise to a soluble target that can also bind therapeutic proteins, is…
Danielle Pillsbury2014 年 1 月 1 日
Cassette Dosing: Advantages and Challenges
Cassette dosing is a technique primarily used in drug discovery efforts in non-clinical studies to…
Nathan Teuscher2013 年 12 月 16 日
Anatomical, Physiological and Metabolic Changes with Gestational Age During Normal Pregnancy: A Database for Parameters Required in Physiologically-based Pharmacokinetic Modeling
Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women.…
Danielle Pillsbury2013 年 12 月 13 日
Bottom-up Modeling and Simulation of Tacrolimus Clearance: Prospective Investigation of Blood Cell Distribution, Sex and CYP3A5 Expression as Covariates and Assessment of Study Power
The objectives were to investigate the ability of population-based in vitro-in vivo extrapolation (IVIVE) to…
Danielle Pillsbury2013 年 12 月 1 日
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment
Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…
Danielle Pillsbury2013 年 12 月 1 日
Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution
In environments where complete mechanistic knowledge of the system dynamics is not available, a synergy…
Danielle Pillsbury2013 年 12 月 1 日
Differences in Cytochrome P450-mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically-based Pharmacokinetic Modeling
International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)…
Danielle Pillsbury2013 年 12 月 1 日
Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel
Pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined…
Danielle Pillsbury2013 年 11 月 24 日
