Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice Publication Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…Certara2014 年 8 月 15 日
Bioanalytical Calibration Curves Knowledge Base Bioanalytical Calibration Curves At the request of a reader, I have decided to extend my series on bioanalysis…Certara2014 年 8 月 12 日
Comparative Benefit of Malaria Chemoprophylaxis Modeled in United Kingdom Travelers Publication Comparative Benefit of Malaria Chemoprophylaxis Modeled in United Kingdom Travelers Certara2014 年 8 月 5 日
Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival Publication Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…Certara2014 年 8 月 1 日
Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information Publication Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling…Certara2014 年 8 月 1 日
Radiometric Analysis Knowledge Base Radiometric Analysis One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…Certara2014 年 7 月 29 日
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor Publication Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…Certara2014 年 7 月 14 日
Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model Publication Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model Compared to small chemical molecules, antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behavior characterized by…Certara2014 年 7 月 9 日
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin Publication Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…Certara2014 年 7 月 9 日
What is HPLC/UV? 知识库 What is HPLC/UV? In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…Certara2014 年 7 月 8 日