pre-update Archives

Publication

Population PK & Dosing Implications for Cobimetinib in Cancer Patients

A population pharmacokinetic model was developed for cobimetinib in cancer patients. Covariates had minimal impact…

Danielle Pillsbury2015 年 11 月 1 日

Publication

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

Bioavailability of orally administered drugs can be influenced by a number of factors including release…

Danielle Pillsbury2015 年 11 月 1 日

Announcement

Introducing OpenCDISC Enterprise 3.0

Pinnacle 21 is proud to announce the launch of OpenCDISC Enterprise 3.0, which will be…

Certara2015 年 10 月 27 日

Publication

Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-release Tablets to Elderly and Young Subjects

Tramadol is frequently used in geriatric patients; however, pharmacokinetic (PK) publications on tramadol and O-desmethyltramadol…

Danielle Pillsbury2015 年 10 月 27 日

Publication

Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs

Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the optimum time is still a challenge in…

Danielle Pillsbury2015 年 10 月 1 日

Blog

How to Optimize Your Drug Label Using Modeling and Simulation Technology

As a trained pharmacist and scientist, I think a lot about patient care and how…

Certara2015 年 9 月 29 日

Knowledge Base

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Over the course of my career, I have taught the theory and practical applications of PK/PD…

Nathan Teuscher2015 年 9 月 15 日

Publication

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

The published OS model and resultant simulations can be leveraged to support Phase II design…

Danielle Pillsbury2015 年 9 月 1 日

Publication

Are Physiologically-based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (Cmax) following intravenous administration. A proposed explanation is that invariably…

Danielle Pillsbury2015 年 9 月 1 日

Knowledge Base

Derivation for Logarithmic Trapezoidal AUC Calculation

Calculating area under the curve requires the use of two separate equations: one is follows…

Nathan Teuscher2015 年 8 月 5 日

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pre-update

Population PK & Dosing Implications for Cobimetinib in Cancer Patients

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

Introducing OpenCDISC Enterprise 3.0

Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-release Tablets to Elderly and Young Subjects

Development of a Multicompartment Permeability-limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs

How to Optimize Your Drug Label Using Modeling and Simulation Technology

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Modeling & Simulation Relating Survival to Tumor Growth Inhibition in Patients

Are Physiologically-based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

Derivation for Logarithmic Trapezoidal AUC Calculation

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