Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations Publication Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations BMS-690514, a selective inhibitor of the ErbB and vascular endothelial growth factor receptors, has shown…Danielle Pillsbury2013 年 2 月 1 日
Bioavailability of Intranasal vs. Rectal Diazepam Publication Bioavailability of Intranasal vs. Rectal Diazepam There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older…Danielle Pillsbury2013 年 2 月 1 日
Analysis of Level A In Vitro-In Vivo Correlations for an Extended-release Formulation with Limited Bioavailability Publication Analysis of Level A In Vitro-In Vivo Correlations for an Extended-release Formulation with Limited Bioavailability A two-stage, numerical deconvolution approach was employed to develop level A in vitro–in vivo correlations…Danielle Pillsbury2013 年 1 月 21 日
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus Publication Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet…Danielle Pillsbury2013 年 1 月 9 日
Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption Publication Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption The use of whole body physiological-based pharmacokinetic (PBPK) models linked with in vitro-in vivo extrapolation…Danielle Pillsbury2013 年 1 月 1 日
Simulations to Assess Phase 2 Non-inferiority Trials of Different Doses of Capecitabine in Combination with Docetaxel for Metastatic Breast Cancer Publication Simulations to Assess Phase 2 Non-inferiority Trials of Different Doses of Capecitabine in Combination with Docetaxel for Metastatic Breast Cancer A phase II trial in metastatic breast cancer (MBC) (NO16853) failed to show noninferiority (progression-free…Danielle Pillsbury2012 年 12 月 26 日
Calculating Urine PK Parameters BlogKnowledge Base Calculating Urine PK Parameters Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…Certara2012 年 12 月 6 日
Novel Biocompatible Disease Modifying Nanomedicine of VIP for Rheumatoid Arthritis Publication Novel Biocompatible Disease Modifying Nanomedicine of VIP for Rheumatoid Arthritis Despite advances in rheumatoid arthritis (RA) treatment, efficacious and safe disease-modifying therapy still represents an…Danielle Pillsbury2012 年 12 月 4 日
What Can We Learn from a Human Mass Balance Study? 知识库 What Can We Learn from a Human Mass Balance Study? Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…Nathan Teuscher2012 年 11 月 27 日
Bioavailability BlogKnowledge Base 生物利用度 Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…Certara2012 年 11 月 4 日