Modeling and Simulation - PK/PD Archives | 第 23 页，共 38 页

Publication

Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin

Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…

Certara2014 年 7 月 9 日

知识库

What is HPLC/UV?

In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…

Certara2014 年 7 月 8 日

Publication

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…

Certara2014 年 6 月 1 日

Publication

The ISoP Standards and Best Practices Committee

The mission of the International Society of Pharmacometrics (ISoP) Standards and Best Practices Committee is…

Certara2014 年 6 月 1 日

Publication

The Posology of Oseltamivir in Infants with Influenza Infection Using a Population Pharmacokinetic Approach

Certara2014 年 5 月 27 日

Publication

Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients

Model-based meta-analysis of dose response is a sophisticated method to guide dose and regimen selection.…

Certara2014 年 5 月 21 日

Blog Knowledge Base

What Can We Learn from Dose Normalization?

Dose normalization is a common calculation performed with pharmacokinetic parameters. The general process is to…

Certara2014 年 5 月 19 日

Publication

Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials

Model-based drug development in oncology is still lagging despite a good momentum in the clinical…

Certara2014 年 4 月 1 日

Publication

Exploratory Modeling and Simulation to Support Development of Motesanib in Asian Patients with Non-small Cell Lung Cancer Based on MONET1 Study Results

The motesanib phase III MONET1 study failed to show improvement in overall survival (OS) in…

Certara2014 年 4 月 1 日

Publication

Physiologically-based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction…

Certara2014 年 3 月 26 日

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Modeling and Simulation – PK/PD

Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin

What is HPLC/UV?

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

The ISoP Standards and Best Practices Committee

The Posology of Oseltamivir in Infants with Influenza Infection Using a Population Pharmacokinetic Approach

Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients

What Can We Learn from Dose Normalization?

Evaluation of Tumor Size Response Metrics to Predict Survival in Oncology Clinical Trials

Exploratory Modeling and Simulation to Support Development of Motesanib in Asian Patients with Non-small Cell Lung Cancer Based on MONET1 Study Results

Physiologically-based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

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