Modeling and Simulation - PK/PD Archives | 第 15 页，共 37 页

Publication

Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication…

Danielle Pillsbury2016 年 6 月 11 日

Blog

Diving into Best Practices for Pooling Clinical Trial Data

Learn the best practices for pooling clinical trial data. Discover how effective data integration enhances…

Certara2016 年 6 月 3 日

Publication

Lessons Learned: Dose Selection of Small Molecule-targeted Oncology Drugs

Danielle Pillsbury2016 年 6 月 1 日

Publication

Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves

OBJECTIVE To describe plasma pharmacokinetic parameters and tissue elimination of flunixin in veal calves. ANIMALS…

Danielle Pillsbury2016 年 6 月 1 日

Publication

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…

Danielle Pillsbury2016 年 6 月 1 日

Publication

Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions

Danielle Pillsbury2016 年 6 月 1 日

Publication

Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Healthy Adult Subjects Following Single and Multiple Ascending Doses

The pharmacokinetics and safety of ceftolozane, a novel cephalosporin, and tazobactam, a β-lactamase inhibitor, alone…

Danielle Pillsbury2016 年 6 月 1 日

Blog

Reference-scaled Average Bioequivalence

The standard approach for approval of generic drugs is to run a bioequivalence study to…

Certara2016 年 5 月 12 日

Publication

Optimization of Vancomycin Dosing Regimens to Achieve Therapeutic Targets in Critically Ill Patients in Thailand

It is essential to rapidly achieve therapeutic vancomycin concentrations in critically ill patients with gram-positive…

Danielle Pillsbury2016 年 5 月 1 日

Publication

Population Pharmacokinetic/Pharmacodynamic Modeling of Tumor Growth Kinetics in Medullary Thyroid Cancer Patients Receiving Cabozantinib

Nonlinear mixed effects models were developed to describe the relationship between cabozantinib exposure and target…

Danielle Pillsbury2016 年 4 月 27 日

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Modeling and Simulation – PK/PD

Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment

Diving into Best Practices for Pooling Clinical Trial Data

Lessons Learned: Dose Selection of Small Molecule-targeted Oncology Drugs

Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions

Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Healthy Adult Subjects Following Single and Multiple Ascending Doses

Reference-scaled Average Bioequivalence

Optimization of Vancomycin Dosing Regimens to Achieve Therapeutic Targets in Critically Ill Patients in Thailand

Population Pharmacokinetic/Pharmacodynamic Modeling of Tumor Growth Kinetics in Medullary Thyroid Cancer Patients Receiving Cabozantinib

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