Modeling and Simulation Archives

Publication

Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux

A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin…

Danielle Pillsbury2013 年 9 月 1 日

Publication

A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine

The interplay between liver metabolizing enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion…

Danielle Pillsbury2013 年 7 月 24 日

Publication

Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption

The use of whole body physiological-based pharmacokinetic (PBPK) models linked with in vitro-in vivo extrapolation…

Danielle Pillsbury2013 年 1 月 1 日

Publication

Population-based Mechanistic Prediction of Oral Drug Absorption

The bioavailability of drugs from oral formulations is influenced by many physiological factors including gastrointestinal…

Danielle Pillsbury2009 年 6 月 1 日

Publication

Accurate and Interpretable Computational Modeling of Chemical Mutagenicity

We describe a method for modeling chemical mutagenicity in terms of simple rules based on…

Danielle Pillsbury2008 年 9 月 5 日

Publication

A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally

BACKGROUND: The spleen tyrosine kinase (Syk) is recognized as a potential pharmaceutical target for the…

Danielle Pillsbury2008 年 7 月 1 日

Publication

A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor

CggR belongs to the SorC family of bacterial transcriptional regulators which control the expression of…

Danielle Pillsbury2008 年 6 月 1 日

Publication

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Early identification of adverse effect of preclinical and commercial drugs is crucial in developing highly…

Danielle Pillsbury2007 年 11 月 1 日

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建模与模拟

Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux

A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine

Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption

Population-based Mechanistic Prediction of Oral Drug Absorption

Accurate and Interpretable Computational Modeling of Chemical Mutagenicity

A Novel Druglike Spleen Tyrosine Kinase Binder Prevents Anaphylactic Shock when Administered Orally

A Phospho-sugar Binding Domain Homologous to NagB Enzymes Regulates the Activity of the Central Glycolytic Genes Repressor

In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

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