Modeling and Simulation Archives

Case Study

利用药代动力学建模和科学传播专长推进肉样瘤病药物项目

Certara's support, from dose optimization to medical writing, helps pharmaceutical companies advance their research, make…

Danielle Pillsbury2023 年 6 月 1 日

Case Study

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Bispecific antibodies are an emerging class of antibodies developed in recent years that provide new…

Danielle Pillsbury2023 年 1 月 23 日

Case Study

Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量

全世界约有 400,000 名先天性肾上腺增生症（CAH）患者。Current therapy for CAH uses a…

Becca Bucci2022 年 6 月 6 日

Case Study

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Quetiapine is an atypical antipsychotic for treating schizophrenia, bipolar depression, bipolar mania that helps to…

Jim Gallagher2021 年 8 月 26 日

Case Study

Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification

Aripiprazole lauroxil (Aristada®) was approved by the FDA for treating schizophrenia in adults in October…

Jim Gallagher2021 年 8 月 12 日

Fact Sheet

Phoenix WinNonlin

Jieun Choe2020 年 6 月 22 日

White Paper

利用 QSP 优化免疫肿瘤药物发现与开发

A Quantitative Systems Pharmacology (QSP) approach for developing combination immune-oncology therapies can be used to…

Danielle Pillsbury2019 年 6 月 19 日

Brochure

Pirana 建模工作平台

Pirana is a flexible and extendible modeling workbench with an intuitive graphical user interface for…

Danielle Pillsbury2019 年 5 月 28 日

Publication

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances

Rosuvastatin is a substrate of choice in clinical studies of organic anion-transporting polypeptide (OATP)1B1- and…

Danielle Pillsbury2016 年 7 月 1 日

Publication

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…

Danielle Pillsbury2016 年 6 月 1 日

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建模与模拟

利用药代动力学建模和科学传播专长推进肉样瘤病药物项目

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification

Phoenix WinNonlin

利用 QSP 优化免疫肿瘤药物发现与开发

Pirana 建模工作平台

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

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