Leveraging Pharmacokinetic Modeling & Scientific Communications Expertise Advances Sarcoidosis Drug Program Case Study 利用药代动力学建模和科学传播专长推进肉样瘤病药物项目 Certara's support, from dose optimization to medical writing, helps pharmaceutical companies advance their research, make…Danielle Pillsbury2023 年 6 月 1 日
Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer Case Study Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer Bispecific antibodies are an emerging class of antibodies developed in recent years that provide new…Danielle Pillsbury2023 年 1 月 23 日
Simcyp Simulator Helps Optimize Drug Dosing in Adults & Adolescents with Orphan Disease Case Study Simcyp Simulator 有助于优化成人和青少年孤儿病患者的用药剂量 全世界约有 400,000 名先天性肾上腺增生症(CAH)患者。Current therapy for CAH uses a…Becca Bucci2022 年 6 月 6 日
Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder Case Study Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder Quetiapine is an atypical antipsychotic for treating schizophrenia, bipolar depression, bipolar mania that helps to…Jim Gallagher2021 年 8 月 26 日
Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification Case Study Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification Aripiprazole lauroxil (Aristada®) was approved by the FDA for treating schizophrenia in adults in October…Jim Gallagher2021 年 8 月 12 日
Optimize Immuno-oncology Drug Discovery and Development Using QSP White Paper 利用 QSP 优化免疫肿瘤药物发现与开发 A Quantitative Systems Pharmacology (QSP) approach for developing combination immune-oncology therapies can be used to…Danielle Pillsbury2019 年 6 月 19 日
Pirana Modeling Workbench Brochure Pirana 建模工作平台 Pirana is a flexible and extendible modeling workbench with an intuitive graphical user interface for…Danielle Pillsbury2019 年 5 月 28 日
More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances Publication More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances Rosuvastatin is a substrate of choice in clinical studies of organic anion-transporting polypeptide (OATP)1B1- and…Danielle Pillsbury2016 年 7 月 1 日
Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data Publication Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…Danielle Pillsbury2016 年 6 月 1 日