Using MBMA to run virtual “head-to-head trials” Case Study 使用 MBMA 进行虚拟 "正面交锋试验" Osteoporosis is common in post-menopausal women. The long-term sequelae of osteoporosis include bone fractures, particularly…Certara2023 年 4 月 21 日
A Bird’s Eye View on Rare Diseases: Key Drug Development Considerations for Thyroid Eye Disease Blog A Bird’s Eye View on Rare Diseases: Key Drug Development Considerations for Thyroid Eye Disease New therapeutics discovery and development for ocular diseases have been traditionally associated with a low…Certara2021 年 12 月 15 日
Using Model-based Meta-analysis to Inform Neuropathic Pain Drug Development Blog Using Model-based Meta-analysis to Inform Neuropathic Pain Drug Development Model-based Meta-analysis is a framework to compare drugs used to treat diabetic peripheral neuropathy, post-herpetic…Certara2019 年 12 月 19 日
Apixaban for treatment of venous thromboembolism (VTEtx): Use of MBMA to support Phase 3 dose selection and beyond Publication Apixaban for treatment of venous thromboembolism (VTEtx): Use of MBMA to support Phase 3 dose selection and beyond Apixaban is an orally available, direct, selective inhibitor of the coagulation factor Xa that reversibly…Certara2018 年 6 月 2 日
Model-informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor Publication Model-informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor Certara2018 年 2 月 15 日
Drug Asset Evaluation: Increasing “Probability of Success” of a Deal White Paper 药物资产评估:提高交易的 "成功概率” Certara’s due diligence/asset evaluation teams are comprised of drug development and commercialization experts who advise…Certara2017 年 8 月 24 日
Model-based Meta-analysis: An Innovative Methodology Comes of Age White Paper 基于模型的荟萃分析(MBMA):创新方法的时代来临了 MBMA integrates internal and external drug development data to inform proprietary commercial and R&D decisions.…Certara2016 年 7 月 14 日
Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis Publication Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis The objective of this study was to assess the relationship between short-term and long-term treatment…Certara2016 年 7 月 1 日
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Publication Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…Certara2015 年 5 月 1 日
A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma Publication A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma PURPOSE: To characterize dose and response for intraocular pressure (IOP) reduction and incidence of hyperemia…Certara2015 年 5 月 1 日