5 Clinical Development Challenges Model-Based Meta-Analysis (MBMA) Helps Address Blog 5 大临床开发挑战 — 基于模型的荟萃分析(MBMA)助力应对 2025 年 6 月 30 日 Drug development is increasingly defined by its complexity. Teams must navigate rising…Certara2025 年 6 月 30 日
From Data to Decisions: Real-World Impact of Model-Based Meta-Analysis (MBMA) with GSK and Certara Webinar 从数据到决策:基于模型的荟萃分析(MBMA)与 GSK 和 Certara 真实世界影响 Certara2025 年 6 月 18 日
A translational model-based meta-analysis to predict tremor incidence associated with serotonin reuptake transporter inhibition Publication 基于转化模型的荟萃分析,预测与血清素再摄取转运体抑制相关的震颤发生率 The serotonin reuptake transporter (SERT) is responsible for the removal and recycling of the neurotransmitter…Certara2025 年 4 月 30 日
Model-Based Meta-Analysis (MBMA) for Relative Treatment Effects and Absolute Outcomes: A Focus on Concepts and Applications On-Demand Webinar 相对治疗效果和绝对结局的基于模型的荟萃分析:聚焦概念与应用 Vice President, MBMA Capability Lead, Certara Drug Development Solutions Matt advances the integration of published…Certara2025 年 4 月 10 日
Model-Based Meta-Analysis for All Phases of Drug Development: Capturing the Full Potential of Published Clinical Trial Outcomes [APAC Webinar] On-Demand Webinar Model-Based Meta-Analysis for All Phases of Drug Development: Capturing the Full Potential of Published Clinical Trial Outcomes [APAC Webinar] Vice President, Quantitative Science Services, Certara Matt advances the integration of published clinical outcomes data…Certara2025 年 4 月 3 日
The Unrealized Potential of Advanced Modeling Methods to Inform Early Strategic Planning for Payer Reimbursement Publication The Unrealized Potential of Advanced Modeling Methods to Inform Early Strategic Planning for Payer Reimbursement This article explores the overlooked yet critical role of early strategic planning for payer reimbursement…Certara2025 年 2 月 25 日
Pharmacometrics Drug Development Decision Support: Model-Based Meta-Analysis (MBMA) Fact Sheet 定量药理学在药物开发中的决策支持:基于模型的荟萃分析(MBMA) Certara2025 年 2 月 19 日
Solving Drug Development Challenges with Model-Based Meta-Analysis (MBMA) On-Demand Webinar 利用基于模型的荟萃分析 (MBMA) 解决药物开发难题 In this on-demand webinar, "MBMA: Optimizing Drug Development with Aggregate Clinical Trial Data and Predictive…Certara2025 年 1 月 9 日
INTERCEPT-AD, a phase 1 study of intravenous sabirnetug in participants with mild cognitive impairment or mild dementia due to Alzheimer’s disease Publication INTERCEPT-AD:一项针对阿尔茨海默病所致轻度认知障碍或轻度痴呆患者的静脉注射 Sabirnetug 的 I 期研究 The Phase 1 INTERCEPT-AD study evaluated sabirnetug (ACU193), a monoclonal antibody targeting amyloid-beta oligomers (AβOs),…Certara2025 年 1 月 8 日
Preclinical data exposures underpredict clinical physiologically active doses for bispecific T-cell engagers in solid tumors indications; are there better metrics? -insights from a small mechanistic MBMA Poster 临床前数据暴露无法预测双特异性 T 细胞吸引剂在实体瘤适应症中的临床生理活性剂量;是否有更好的衡量标准?— 来自小型机制性 MBMA 的启示 Certara2024 年 12 月 11 日