Publication

Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

Discover how major CYP2C19 genotype effects on voriconazole PK, supporting genotype‑guided dose adjustments to avoid…

Certara2022 年 1 月 3 日

Publication

The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers

See how rifampicin reduces fuzuloparib exposure by up to 90%, confirming a major CYP3A4 induction…

Certara2021 年 12 月 26 日

Publication

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma

Find out how lower vinorelbine exposure in children and strong BSA effects, supporting dose refinement…

Certara2021 年 12 月 13 日

Publication

Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections

Learn how adjusted‑body‑weight dosing optimises polymyxin B exposure in obese patients, avoiding toxicity while achieving…

Certara2021 年 11 月 22 日

On-Demand Webinar

预测和驯化免疫原性：生物药物策略

Immunogenicity is the ability of a foreign substance, such as a drug or vaccine, to…

Certara2021 年 11 月 19 日

Case Study

Dose Optimization Using Population PK for an Orphan Drug

RAPALIMUS® Tablets (sirolimus) is Nobelpharma’s orphan drug developed from an oral medication that is sold…

Certara2021 年 11 月 17 日

Publication

A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats

Explore how altered PK of fenugreek bioactives in diabetic rats, with faster absorption and slower…

Certara2021 年 11 月 16 日

Publication

Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects

Discover how bioequivalence of generic and branded budesonide nasal sprays, with matched PK and strong…

Certara2021 年 11 月 16 日

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