Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain
The aim of this study was to develop a pain relief model for a cyclooxygenase…
Certara2008 年 7 月 1 日
Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems
Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…
Certara2007 年 9 月 1 日
Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor
The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…
Certara2007 年 3 月 1 日
Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA
The aim of this study was to model the in vivo kinetic consequences of mechanism-based…
Certara2006 年 11 月 1 日
Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor
A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…
Certara2006 年 5 月 1 日
Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation
The aim of this study was to develop a pain relief model for a cyclooxygenase…
Certara2006 年 4 月 1 日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation
A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…
Certara2005 年 9 月 1 日
The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain
Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…
Certara2003 年 11 月 1 日
