Model-based Meta-analysis: An Innovative Methodology Comes of Age
MBMA integrates internal and external drug development data to inform proprietary commercial and R&D decisions.…
webdev2016 年 7 月 14 日
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9
RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…
webdev2015 年 3 月 31 日
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors
Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…
webdev2015 年 1 月 1 日
Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice
Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…
webdev2014 年 8 月 15 日
An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment
Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…
webdev2013 年 12 月 1 日
Predicted Heart Rate Effect of Inhaled LABA PF-00610355 in Volunteers and COPD Patients
The aim of this study was to assess the cardiovascular effects of a new inhaled…
webdev2013 年 11 月 1 日
Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide
CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…
webdev2013 年 4 月 1 日
Characterization of Exposure Versus Response of Edoxaban in Patients Undergoing Total Hip Replacement Surgery
Edoxaban is an oral direct factor Xa inhibitor approved for the prevention of venous thromboembolism…
webdev2012 年 11 月 1 日
