Over the past 25 years, physiologically based pharmacokinetic (PBPK) modeling has revolutionized our understanding of drug-drug interactions (DDIs). This retrospective will delve into the profound impact PBPK has had on the field, not only advancing the science and knowledge but also transforming the culture of research groups. By moving away from traditional methods and embracing mechanistic modeling, PBPK has provided a framework for predicting complex DDIs with greater accuracy and insight. This approach has fostered a collaborative mindset, encouraging continuous learning and innovation and a shift from empirical data to rational, model-based predictions. Watch as we explore how PBPK has become an indispensable tool in drug development.

Key takeaways:

Advanced DDI Prediction: PBPK modeling has significantly improved drug-drug interaction understanding and predictions.

Cultural Shift: PBPK has fostered a collaborative and innovative research culture.

Practical Impact: PBPK is essential for understanding complex drug interactions and driving a deeper mechanistic understanding of the drivers of DDI.