Publication Archives

Publication

Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain

Capsaicin, a pungent compound in chili peppers, is a highly selective agonist for the transient…

Certara2009 年 8 月 1 日

Publication

The Conduct of In Vitro Studies to Address Time-dependent Inhibition of Drug-metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America (PhRMA)

Time-dependent inhibition (TDI) of cytochrome P450 (P450) enzymes caused by new molecular entities (NMEs) is…

Certara2009 年 7 月 1 日

Publication

In Vitro and In Vivo Induction of Cytochrome p450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

Cytochrome P450 (P450) induction is one of the factors that can affect the pharmacokinetics of a drug…

Certara2009 年 7 月 1 日

Publication

The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions

We identify some innovative approaches to predicting overall patient benefit from investigational drugs to support…

Certara2009 年 7 月 1 日

Publication

Assessing the Efficiency of Mixed Effects Modeling in Quantifying Metabolism-based Drug-drug Interactions: Using In Vitro Data as an Aid to Assess Study Power

The clinical assessment of metabolic drug-drug interactions (mDDI) may involve population-based pharmacokinetic (POPPK) assessment as…

Certara2009 年 7 月 1 日

Publication

Physiologically-based Pharmacokinetics (PBPK)

Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many…

Certara2009 年 6 月 1 日

Publication

In Vitro and In Silico Identification and Characterization of Thiabendazole as a Mechanism-based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-drug Interactions

Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2.…

Certara2009 年 6 月 1 日

Publication

Population-based Mechanistic Prediction of Oral Drug Absorption

The bioavailability of drugs from oral formulations is influenced by many physiological factors including gastrointestinal…

Certara2009 年 6 月 1 日

Publication

Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction

Although CYP induction is not generally considered to be as clinically relevant as CYP inhibition,…

Certara2009 年 5 月 1 日

Publication

In Vitro and In Vivo Glucuronidation of Midazolam in Humans

Midazolam (MDZ) is a benzodiazepine used as a CYP3A4 probe in clinical and in vitro studies. A…

Certara2009 年 4 月 1 日

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Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain

The Conduct of In Vitro Studies to Address Time-dependent Inhibition of Drug-metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America (PhRMA)

In Vitro and In Vivo Induction of Cytochrome p450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective

The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions

Assessing the Efficiency of Mixed Effects Modeling in Quantifying Metabolism-based Drug-drug Interactions: Using In Vitro Data as an Aid to Assess Study Power

Physiologically-based Pharmacokinetics (PBPK)

In Vitro and In Silico Identification and Characterization of Thiabendazole as a Mechanism-based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-drug Interactions

Population-based Mechanistic Prediction of Oral Drug Absorption

Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction

In Vitro and In Vivo Glucuronidation of Midazolam in Humans

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