Using Sampling “Windows” for PK Blood Samples
One of the most common questions posed by clinical operations experts when including pharmacokinetic sampling…
Certara2013 年 10 月 15 日
Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body
When I first began learning about pharmacokinetics, I was often confused by the mean residence…
Certara2013 年 3 月 28 日
The Superposition Principle
Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…
Certara2013 年 3 月 14 日
Saturable Drug Absorption
Drug absorption is the process by which a drug molecule moves from the site of…
Certara2013 年 2 月 26 日
Nonlinear PK: What Does That Mean?
You may come across a phrase like the following and wonder what it means: “……
Certara2013 年 2 月 17 日
Why Cmax is a Continuous Variable and Tmax is a Categorical Variable
The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…
Certara2013 年 2 月 11 日
What is Quantification Anyway?
Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…
Certara2013 年 2 月 5 日
Calculating Urine PK Parameters
Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…
Certara2012 年 12 月 6 日
What Can We Learn from a Human Mass Balance Study?
Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”.…
Certara2012 年 11 月 27 日
Bioavailability
Discover bioavailability in pharmacokinetics, its types, the first-pass effect, and calculations. Explore tools for accurate…
Certara2012 年 11 月 4 日
