In this poster, we explore the cutting edge of oncology research with our minimal PBPK/PD mouse model, designed specifically for 212Pb-based Radio-DARPin MP0712. This advanced model targets DLL3, a critical factor in small cell lung cancer, offering valuable insights into tumor-targeting efficacy and therapeutic optimization. By integrating advanced computational modeling with empirical data, this minimalistic framework serves as a bridge between scientific innovation and practical therapeutic applications.