Time-dependent CYP Inhibition
Time-dependent inhibition (TDI) of CYP refers to a change in potency during an in vitro incubation or dosing period…
Danielle Pillsbury2007 年 2 月 1 日
Simulation and Prediction of In Vivo Drug Metabolism in Human Populations from In Vitro Data
The perceived failure of new drug development has been blamed on deficiencies in in vivo…
Danielle Pillsbury2007 年 2 月 1 日
Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance from In Vitro Data: Reaching a Consensus on Values of Human Microsomal Protein and Hepatocellularity per Gram of Liver
Reported predictions of human in vivo hepatic clearance from in vitro data have used a…
Danielle Pillsbury2007 年 1 月 1 日
Prediction of Plasma Protein Binding Displacement and Its Implications for Quantitative Assessment of Metabolic Drug-drug Interactions from In Vitro Data
Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should…
Danielle Pillsbury2006 年 12 月 1 日
Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA
The aim of this study was to model the in vivo kinetic consequences of mechanism-based…
Danielle Pillsbury2006 年 11 月 1 日
The Impact of Experimental Design on Assessing Mechanism-based Inactivation of CYP2D6 by MDMA (Ecstasy)
MDMA (3-4-methylenedioxymethamphetamine, commonly known as Ecstasy) is a potent mechanism-based inhibitor (MBI) of cytochrome P450…
Danielle Pillsbury2006 年 11 月 1 日
Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates
Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…
Danielle Pillsbury2006 年 9 月 1 日
Prediction of Metabolic Drug Clearance in Humans: In Vitro-In Vivo Extrapolation vs Allometric Scaling
Previously in vitro-in vivo extrapolation (IVIVE) with the Simcyp Clearance and Interaction Simulator® has been…
Danielle Pillsbury2006 年 7 月 1 日
Prediction of In Vivo Drug Clearance from In Vitro Data, I: Impact of Inter-individual Variability
The Simcyp® Population-Based ADME Simulator was used to predict median drug clearances and their associated…
Danielle Pillsbury2006 年 6 月 1 日
Prediction of In Vivo Drug Clearance from In Vitro Data, II: Potential Inter-ethnic Differences
Potential differences in drug clearance between Japanese and Caucasians were investigated by integrating data on…
Danielle Pillsbury2006 年 6 月 1 日
