pre-update Archives

Publication

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Three approaches were compared to predict the actual magnitude of drug interaction (the mean fold-change in the area under…

Danielle Pillsbury2007 年 10 月 1 日

Publication

Prediction of Intestinal First-pass Drug Metabolism

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium compared to…

Danielle Pillsbury2007 年 10 月 1 日

Publication

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

An analysis of reported hepatic abundances of CYP3A4 and 3A5 indicated that values determined by…

Danielle Pillsbury2007 年 10 月 1 日

Publication

A Systematic Comparison of Software Dedicated to Meta-analysis of Causal Studies

Our objective was to systematically assess the differences in features, results, and usability of currently…

Danielle Pillsbury2007 年 9 月 10 日

Publication

Modeling, Simulation, and the Critical Path

The benefits of modeling and simulation fall into two categories: Increased certainty in trial designs…

Danielle Pillsbury2007 年 9 月 6 日

Publication

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…

Danielle Pillsbury2007 年 9 月 1 日

Publication

Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (time)-based Enzyme Inhibition

We have shown previously that the conventional experimental protocol (CEP) used to characterise mechanism-based enzyme…

Danielle Pillsbury2007 年 7 月 1 日

Publication

The Use of Mechanistic DM-PK-PD Modeling to Assess the Power of Pharmacogenetic Studies—CYP2C9 and Warfarin as an Example

The aim of this study was to assess the power of in vivo studies needed…

Danielle Pillsbury2007 年 7 月 1 日

Publication

Kinetics of the Time-dependent Inactivation of CYP2D6 in Cryopreserved Human Hepatocytes by Methylenedioxymethamphetamine (MDMA)

Methylenedioxymethamphetamine (MDMA) was investigated in cryopreserved human hepatocytes as a time-dependent inactivator (TDI) of CYP2D6…

Danielle Pillsbury2007 年 5 月 1 日

Publication

The Problems in Scaling Adult Drug Doses to Children

Many drugs are unlicensed in children and consequently their doses have been scaled down from…

Danielle Pillsbury2007 年 3 月 15 日

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pre-update

Comparison of Different Approaches to Predict Metabolic Drug-drug Interactions

Prediction of Intestinal First-pass Drug Metabolism

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

A Systematic Comparison of Software Dedicated to Meta-analysis of Causal Studies

Modeling, Simulation, and the Critical Path

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Theoretical Assessment of a New Experimental Protocol for Determining Kinetic Values Describing Mechanism (time)-based Enzyme Inhibition

The Use of Mechanistic DM-PK-PD Modeling to Assess the Power of Pharmacogenetic Studies—CYP2C9 and Warfarin as an Example

Kinetics of the Time-dependent Inactivation of CYP2D6 in Cryopreserved Human Hepatocytes by Methylenedioxymethamphetamine (MDMA)

The Problems in Scaling Adult Drug Doses to Children

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