pre-update Archives

Publication

Poor Correlation between Urinary Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by a Stable Isotope Method in Epilepsy Patients

The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been…

Certara2011 年 2 月 1 日

Publication

Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science

The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of age in drug development and…

Certara2011 年 2 月 1 日

Publication

Unexpected Effect of Rifampin on the Pharmacokinetics of Linezolid: In Silico and In Vitro Approaches to Explain Its Mechanism

The effect of rifampin on the steady-state pharmacokinetics of linezolid was evaluated in an open-label,…

Certara2011 年 2 月 1 日

Publication

Critique of the Two-fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-drug Interactions

Current assessment of drug-drug interaction (DDI) prediction success is based on whether predictions fall within a two-fold range of the observed data. This strategy…

Certara2011 年 2 月 1 日

Publication

Applications of Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can help predict the…

Certara2011 年 2 月 1 日

Publication

Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides

Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…

Certara2011 年 2 月 1 日

Publication

Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery

A combination of general anesthesia (GA) with thoracic epidural anesthesia (TEA) may have a beneficial…

Certara2011 年 2 月 1 日

Knowledge Base

Relationship Between AUC and Volume of Distribution

A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…

Certara2011 年 1 月 26 日

Knowledge Base

Generics and Bioequivalence

As the debate about health care in the United States continues forward, the term “generic…

Certara2011 年 1 月 10 日

知识库

What are Drug-drug Interactions Anyway?

A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…

Certara2011 年 1 月 5 日

pre-update

Poor Correlation between Urinary Excretion of the Principal Urinary Metabolites of Phenytoin and Absolute Oral Bioavailability Determined by a Stable Isotope Method in Epilepsy Patients

Physiologically-based Pharmacokinetics in Drug Development and Regulatory Science

Unexpected Effect of Rifampin on the Pharmacokinetics of Linezolid: In Silico and In Vitro Approaches to Explain Its Mechanism

Critique of the Two-fold Measure of Prediction Success for Ratios: Application for the Assessment of Drug-drug Interactions

Applications of Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides

Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery

Relationship Between AUC and Volume of Distribution

Generics and Bioequivalence

What are Drug-drug Interactions Anyway?

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