Beyond Publication Bias
In drug development, clinical medicine, or health policy making, basing one's decisions on a selective…
Certara2011 年 5 月 1 日
The Development of UGT1A1 and 1A6 in the Pediatric Liver
UDP-glucuronosyltransferases (UGTs) are critical for the metabolism and clearance of drugs, chemicals, and hormones. The…
Certara2011 年 5 月 1 日
Towards a Better Prediction of Peak Concentration, Volume of Distribution, and Half-life After Oral Drug Administration in Man, Using Allometry
It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin…
Certara2011 年 5 月 1 日
Pharmacokinetics of Clofarabine in Patients with High-risk Inherited Metabolic Disorders Undergoing Brain-sparing Hematopoietic Cell Transplantation
Clofarabine, a newer purine analog with reduced central nervous system toxicity, may prove advantageous in…
Certara2011 年 5 月 1 日
Estimating Toxicity-related Biological Pathway Altering Doses for High-throughput Chemical Risk Assessment
We describe a framework for estimating the human dose at which a chemical significantly alters…
Certara2011 年 4 月 18 日
Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients
TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of…
Certara2011 年 4 月 12 日
In Silico Prediction of Efavirenz and Rifampicin Drug-drug Interaction Considering Weight and CYP2B6 Phenotype
This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data…
Certara2011 年 4 月 1 日
Systematic Review: Diagnostic Accuracy of Clinical Decision Rules for Venous Thromboembolism in Elderly
Physicians committed to the care of elderly patients are challenged with the diagnosis of venous…
Certara2011 年 4 月 1 日
Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model
Prediction of metabolic clearance in extreme individuals rather than the 'average human' is becoming an…
Certara2011 年 3 月 24 日
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
Certara2011 年 3 月 21 日
