pre-update Archives

Publication

Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

The maintenance dose of a drug is dependent on drug clearance, and thus any biochemical…

Danielle Pillsbury2011 年 12 月 1 日

Publication

Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies

Reviews of the productivity of the pharmaceutical industry have concluded that the current business model…

Danielle Pillsbury2011 年 11 月 18 日

Publication

The Proton Pump Inhibitor, Omeprazole, but not Lansoprazole or Pantoprazole, is a Metabolism-dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and…

Danielle Pillsbury2011 年 11 月 1 日

Publication

Determination of Time-dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocyte and Assessment of Human Drug-drug Interactions

Assessment of time-dependent inhibition (TDI), especially CYP3A4, is an important parameter for preclinical and clinical…

Danielle Pillsbury2011 年 11 月 1 日

Publication

Pharmacokinetics of Voriconazole Administered Concomitantly with Fluconazole and Population-based Simulation for Sequential Use

In clinical practice, antifungal therapy may be switched from fluconazole to voriconazole; such sequential use…

Danielle Pillsbury2011 年 11 月 1 日

刊物

Effect of Different Durations and Formulations of Diltiazem on the Single-dose Pharmacokinetics of Midazolam: How Long Do We Go?

Understanding how inhibition of cytochrome P4503A (CYP3A) affects the metabolism of a new drug is…

Danielle Pillsbury2011 年 11 月 1 日

Publication

Prediction of Drug-drug Interactions Arising from Mechanism-based Inactivation: Key Input Parameters and Impact on Risk Assessment

As the prevalence of polypharmacy increases with our aging population, the propensity for adverse drug-drug…

Danielle Pillsbury2011 年 11 月 1 日

知识库

什么是 PK/PD 分析中的滞后现象？

I apologize to all my readers for such a long lapse between posts. After a…

Nathan Teuscher2011 年 10 月 26 日

Publication

Safety and Population Pharmacokinetic Analysis of Intravenous Acetaminophen in Neonates, Infants, Children, and Adolescents with Pain or Fever

The administration of acetaminophen via the oral and rectal routes may be contraindicated in specific…

Danielle Pillsbury2011 年 10 月 16 日

Publication

Risk Assessment of Accidental Nortriptyline Poisoning: The Importance of Cytochrome P450 for Nortriptyline Elimination Investigated Using a Population-based Pharmacokinetic Simulator

It is not possible to make a prospective clinical study that reveals the importance of…

Danielle Pillsbury2011 年 10 月 9 日

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pre-update

Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies

The Proton Pump Inhibitor, Omeprazole, but not Lansoprazole or Pantoprazole, is a Metabolism-dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

Determination of Time-dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocyte and Assessment of Human Drug-drug Interactions

Pharmacokinetics of Voriconazole Administered Concomitantly with Fluconazole and Population-based Simulation for Sequential Use

Effect of Different Durations and Formulations of Diltiazem on the Single-dose Pharmacokinetics of Midazolam: How Long Do We Go?

Prediction of Drug-drug Interactions Arising from Mechanism-based Inactivation: Key Input Parameters and Impact on Risk Assessment

什么是 PK/PD 分析中的滞后现象？

Safety and Population Pharmacokinetic Analysis of Intravenous Acetaminophen in Neonates, Infants, Children, and Adolescents with Pain or Fever

Risk Assessment of Accidental Nortriptyline Poisoning: The Importance of Cytochrome P450 for Nortriptyline Elimination Investigated Using a Population-based Pharmacokinetic Simulator

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