pre-update Archives

Publication

Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

The pharmacokinetics of ibuprofen were studied under microgravity (µG) conditions and compared with those at…

Certara2011 年 12 月 1 日

Publication

Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis

A population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in…

Certara2011 年 12 月 1 日

Publication

Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient…

Certara2011 年 12 月 1 日

Publication

Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis

Information on the comparative effectiveness of drugs is crucial for drug development decisions, in addition…

Certara2011 年 12 月 1 日

Publication

A Dose-response Meta-analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

We present a dose-response meta-analysis to quantify relative efficacy of biologic disease-modifying antirheumatic drugs (DMARDs)…

Certara2011 年 12 月 1 日

Publication

Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

The maintenance dose of a drug is dependent on drug clearance, and thus any biochemical…

Certara2011 年 12 月 1 日

Publication

Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies

Reviews of the productivity of the pharmaceutical industry have concluded that the current business model…

Certara2011 年 11 月 18 日

Publication

The Proton Pump Inhibitor, Omeprazole, but not Lansoprazole or Pantoprazole, is a Metabolism-dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and…

Certara2011 年 11 月 1 日

Publication

Determination of Time-dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocyte and Assessment of Human Drug-drug Interactions

Assessment of time-dependent inhibition (TDI), especially CYP3A4, is an important parameter for preclinical and clinical…

Certara2011 年 11 月 1 日

Publication

Pharmacokinetics of Voriconazole Administered Concomitantly with Fluconazole and Population-based Simulation for Sequential Use

In clinical practice, antifungal therapy may be switched from fluconazole to voriconazole; such sequential use…

Certara2011 年 11 月 1 日

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pre-update

Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans

Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis

Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond

Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis

A Dose-response Meta-analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis

Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance

Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies

The Proton Pump Inhibitor, Omeprazole, but not Lansoprazole or Pantoprazole, is a Metabolism-dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

Determination of Time-dependent Inactivation of CYP3A4 in Cryopreserved Human Hepatocyte and Assessment of Human Drug-drug Interactions

Pharmacokinetics of Voriconazole Administered Concomitantly with Fluconazole and Population-based Simulation for Sequential Use

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