What is “Adjusted” r-squared?
Linear regression is a common tool that the pharmacokineticist uses to calculate elimination rate constants.…
Nathan Teuscher2013 年 10 月 7 日
Inter-individual Variability in Levels of Human Microsomal Protein and Hepatocellularity per Gram of Liver
This study sought to determine levels of microsomal protein (MPPGL) and hepatocellularity (HPGL) per gram…
webdev2013 年 10 月 1 日
Differential Pharmacokinetics of Ganitumab in Patients with Metastatic Pancreatic Cancer Versus Other Advanced Solid Cancers
Ganitumab is an investigational, fully human monoclonal antibody antagonist of the insulin-like growth factor-1 receptor…
webdev2013 年 10 月 1 日
Exposure-response Analysis of Pertuzumab in HER2-positive Metastatic Breast Cancer: Absence of Effect on QTc Prolongation and Other ECG Parameters
The phase III trial of pertuzumab plus trastuzumab plus docetaxel versus placebo plus trastuzumab plus…
webdev2013 年 9 月 3 日
Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol Intoxication: Evaluation of Potential Treatment Strategies
γ-Hydroxybutyrate (GHB), a common drug of abuse, is often coingested with ethanol. Increasing renal clearance…
webdev2013 年 9 月 1 日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux
A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin…
webdev2013 年 9 月 1 日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part II—Prediction of P-glycoprotein Mediated Drug-drug Interactions with Digoxin
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo.…
webdev2013 年 9 月 1 日
