Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody Publication Application of Knockout Mouse Models to Investigate the Influence of FcγR on the Pharmacokinetics and Anti-platelet Effects of MWReg30, a Monoclonal Anti-GPIIb Antibody This work evaluates the influence of FcγR on the pharmacokinetics and pharmacodynamics of a rat…Certara2013 年 2 月 28 日
Saturable Drug Absorption Knowledge Base Saturable Drug Absorption Drug absorption is the process by which a drug molecule moves from the site of…Certara2013 年 2 月 26 日
Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology Publication Systems Pharmacology of the Nerve Growth Factor Pathway: Use of a Systems Biology Model for the Identification of Key Drug Targets Using Sensitivity Analysis and the Integration of Physiology and Pharmacology The nerve growth factor (NGF) pathway is of great interest as a potential source of…Certara2013 年 2 月 21 日
Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? 刊物 Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan? Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in…Certara2013 年 2 月 20 日
What is Quantification Anyway? 知识库 What is Quantification Anyway? Bioanalytical analysis is a fundamental tool for the pharmacokineticist. The results of a bioanalysis are…Certara2013 年 2 月 5 日
Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations Publication Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction with Physiologically-based Pharmacokinetic Simulations BMS-690514, a selective inhibitor of the ErbB and vascular endothelial growth factor receptors, has shown…Certara2013 年 2 月 1 日
Bioavailability of Intranasal vs. Rectal Diazepam Publication Bioavailability of Intranasal vs. Rectal Diazepam There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older…Certara2013 年 2 月 1 日
Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Publication Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the…Certara2013 年 2 月 1 日
Analysis of Level A In Vitro-In Vivo Correlations for an Extended-release Formulation with Limited Bioavailability Publication Analysis of Level A In Vitro-In Vivo Correlations for an Extended-release Formulation with Limited Bioavailability A two-stage, numerical deconvolution approach was employed to develop level A in vitro–in vivo correlations…Certara2013 年 1 月 21 日
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus Publication Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet…Certara2013 年 1 月 9 日