Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning Publication Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning The objective of this study was to investigate the effects of carprofen administered immediately before…Danielle Pillsbury2016 年 2 月 1 日
Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases Publication Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases Danielle Pillsbury2016 年 2 月 1 日
Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application Publication Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application In vitro-in vivo extrapolation of clearance, embedded in a clinical trial simulation, was used to…Danielle Pillsbury2016 年 2 月 1 日
Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy Publication Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy Danielle Pillsbury2016 年 1 月 5 日
Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield Publication Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield Previous research has shown that postpartum administration of the nonsteroidal antiinflammatory drug (NSAID) sodium salicylate…Danielle Pillsbury2016 年 1 月 1 日
Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis Publication Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…Danielle Pillsbury2016 年 1 月 1 日
A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins Publication A Bottom-up Whole-body Physiologically-based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins Danielle Pillsbury2016 年 1 月 1 日
Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko Blog Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…Certara2015 年 12 月 1 日
Modeling the Influence of Ethnicity on Drug Disposition Blog Modeling the Influence of Ethnicity on Drug Disposition Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…Certara2015 年 11 月 23 日
9 Frequently Misunderstood Concepts in PK/PD Modeling Knowledge Base 9 Frequently Misunderstood Concepts in PK/PD Modeling In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…Nathan Teuscher2015 年 11 月 3 日