Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield
Previous research has shown that postpartum administration of the nonsteroidal antiinflammatory drug (NSAID) sodium salicylate…
Certara2016 年 1 月 1 日
Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis
Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…
Certara2016 年 1 月 1 日
Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko
Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…
Certara2015 年 12 月 1 日
Modeling the Influence of Ethnicity on Drug Disposition
Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…
Certara2015 年 11 月 23 日
9 Frequently Misunderstood Concepts in PK/PD Modeling
In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…
Certara2015 年 11 月 3 日
Population PK & Dosing Implications for Cobimetinib in Cancer Patients
A population pharmacokinetic model was developed for cobimetinib in cancer patients. Covariates had minimal impact…
Certara2015 年 11 月 1 日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model
Bioavailability of orally administered drugs can be influenced by a number of factors including release…
Certara2015 年 11 月 1 日
Introducing OpenCDISC Enterprise 3.0
Pinnacle 21 is proud to announce the launch of OpenCDISC Enterprise 3.0, which will be…
Certara2015 年 10 月 27 日
