Study Reanalysis Using a Mechanism-based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes
This report describes a pharmacokinetic/pharmacodynamic model for pramlintide, an amylinomimetic, in type 1 diabetes mellitus…
Certara2015 年 1 月 1 日
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
Certara2014 年 7 月 14 日
Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects with Type 2 Diabetes Mellitus
The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet…
Certara2013 年 1 月 9 日
Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites
The purpose of this analysis was to develop a population pharmacokinetic model for CS-917, an…
Certara2012 年 3 月 1 日
The Use of Biosimulation in the Design of a Novel Multilevel Weight Loss Maintenance Program for Overweight Children
Weight loss outcomes achieved through conventional behavior change interventions are prone to deterioration over time.…
Certara2010 年 2 月 18 日
CYP2D6 is Primarily Responsible for the Metabolism of Clomiphene
Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response to…
Certara2008 年 4 月 30 日
