A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine Publication A Mechanistic Framework for In Vitro-In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug-drug Interaction Between Rosuvastatin and Cyclosporine The interplay between liver metabolizing enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion…Certara2013 年 7 月 24 日
Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption Publication Absolute Abundance and Function of Intestinal Drug Transporters: A Prerequisite for Fully Mechanistic In Vitro-In Vivo Extrapolation of Oral Drug Absorption The use of whole body physiological-based pharmacokinetic (PBPK) models linked with in vitro-in vivo extrapolation…Certara2013 年 1 月 1 日
Applications of Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review Publication Applications of Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can help predict the…Certara2011 年 2 月 1 日
Population-based Mechanistic Prediction of Oral Drug Absorption Publication Population-based Mechanistic Prediction of Oral Drug Absorption The bioavailability of drugs from oral formulations is influenced by many physiological factors including gastrointestinal…Certara2009 年 6 月 1 日
Model-based Development of Gemcabene, a New Lipid-altering Agent Publication Model-based Development of Gemcabene, a New Lipid-altering Agent The purpose of this study was to evaluate the value of model-based, quantitative decision making…Certara2005 年 10 月 7 日