Reference-scaled Average Bioequivalence Blog Reference-scaled Average Bioequivalence The standard approach for approval of generic drugs is to run a bioequivalence study to…Certara2016 年 5 月 12 日
Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates with Estron e-3-Sulfate Transport in Caco-2 Publication Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates with Estron e-3-Sulfate Transport in Caco-2 Transporter mRNA and protein expression data are used to extrapolate in vitro transporter kinetics to in…Danielle Pillsbury2016 年 4 月 1 日
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part I—A Cross-laboratory Comparison of Transporter-protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells Publication In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part I—A Cross-laboratory Comparison of Transporter-protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells Over the last 5 years the quantification of transporter-protein absolute abundances has dramatically increased in parallel to the expanded…Danielle Pillsbury2016 年 3 月 1 日
In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II—The Impact of Cross-laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition Publication In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II—The Impact of Cross-laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition Relative expression factors (REFs) are used to scale in vitro transporter kinetic data via in vitro-in vivo extrapolation linked to physiologically based pharmacokinetic (IVIVE-PBPK)…Danielle Pillsbury2016 年 3 月 1 日
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? 博客 Conventional & Mechanistic IVIVC: Complementary or Clashing Methods? An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…Certara2016 年 2 月 9 日
Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko Blog Back to the Future (of Pharmacometrics) with Dr. Lawrence Lesko Pharmacometrics uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions…Certara2015 年 12 月 1 日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model Publication Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model Bioavailability of orally administered drugs can be influenced by a number of factors including release…Danielle Pillsbury2015 年 11 月 1 日
Introducing OpenCDISC Enterprise 3.0 Announcement Introducing OpenCDISC Enterprise 3.0 Pinnacle 21 is proud to announce the launch of OpenCDISC Enterprise 3.0, which will be…Certara2015 年 10 月 27 日
Max Kanevsky named to the PharmaVOICE 100 List of the Most Inspiring People Announcement Max Kanevsky named to the PharmaVOICE 100 List of the Most Inspiring People Certara’s Pinnacle 21 is honored to announce that Max Kanevsky, has been named to the…Certara2015 年 8 月 5 日
Common Misconceptions About Computer System Validation Blog 关于计算机系统验证的常见误解 Drug development professionals frequently use computer systems to help them understand the pharmacokinetics (PK) and…Certara2015 年 1 月 28 日