Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor Publication Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…webdev2007 年 3 月 1 日
Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA Publication Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA The aim of this study was to model the in vivo kinetic consequences of mechanism-based…webdev2006 年 11 月 1 日
Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor Publication Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…webdev2006 年 5 月 1 日
Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation Publication Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation The aim of this study was to develop a pain relief model for a cyclooxygenase…webdev2006 年 4 月 1 日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation Publication Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…webdev2005 年 9 月 1 日
The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain Publication The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…webdev2003 年 11 月 1 日