分布式延迟系统是离散延迟系统的延伸，在离散延迟系统中，单一延迟时间由延迟时间的分布来表示。口服药物的分布式吸收时间就是一个具有分布式延迟的药代动力学（PK）系统的例子。另一个例子是具有分布式寿命的造血细胞群。
The topic of this webinar is to introduce mathematical tools to model pharmacokinetic/pharmacodynamic (PK/PD) systems with distributed delays. These models will be implemented in Phoenix NLME by means of the delay() operator. A distributed delay version of the transit compartment model for oral drug absorption will be provided. A distributed lifespan PD model of RBC production will be also discussed.
About Our Speaker
Dr. Wojciech Krzyzanski is an Associate Professor of Pharmaceutical Sciences at the University at Buffalo, State University of New York (UB). Dr. Krzyzanski holds a PhD in applied mathematics and a MA in pharmacology. His PK/PD modeling interests and capabilities include the modeling of pharmacokinetics and pharmacodynamics of hematopoietic growth factors, the model-based development of optimal dosing regimens for chemotherapy induced cytotoxicities, particularly myelosuppression, the pharmacometric analysis of properties of various types of indirect response models, and the evolution of target-mediated PK/PD models.
分布式延迟系统是离散延迟系统的延伸，在离散延迟系统中，单一延迟时间由延迟时间的分布来表示。口服药物的分布式吸收时间就是一个具有分布式延迟的药代动力学（PK）系统的例子。另一个例子是具有分布式寿命的造血细胞群。
The topic of this webinar was to introduce mathematical tools to model pharmacokinetic/pharmacodynamic (PK/PD) systems with distributed delays. These models were implemented in Phoenix NLME by means of the delay() operator. A distributed delay version of the transit compartment model for oral drug absorption was provided. A distributed lifespan PD model of RBC production was also discussed.
