Renee Fisher

On-Demand Webinar

引导分子胶降解剂（Molecular Glue Degrader）的目标和先导优化

Learn how to optimize drug properties for protein degrader therapeutics by exploring system characteristics.

Renee Fisher2024 年 10 月 31 日

On-Demand Webinar

通过机制建模捕捉 CAR-T 细胞疗法的动态变化

摘要：Chimeric antigen receptor T (CAR T)-cell therapy has shown remarkable success in treating various…

Renee Fisher2024 年 10 月 31 日

Blog

数学模型有助于扩大免疫肿瘤药物治疗自身免疫疾病的应用范围

Connecting Cancer and Autoimmunity "The dosing regimens in oncology may not directly inform the optimal…

Renee Fisher2024 年 10 月 31 日

Blog

Mathematical Modeling and the Monkey King: Use of Modeling for More Efficient NHP Study Design

Background Monkeys and humans share a strong bond, reflected not only in a shared genetic…

Renee Fisher2024 年 10 月 30 日

Publication

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment

摘要：T cell interaction in the tumor microenvironment is a key component of immuno-oncology therapy.…

Renee Fisher2024 年 10 月 29 日

Publication

早期可行性评估：准确预测生物治疗剂量的方法，为早期药物研发决策提供依据

Early Feasibility Assessment (EFA) can impact early drug discovery decisions such as determining feasibility of…

Renee Fisher2024 年 10 月 29 日

On-Demand Webinar

早期可行性评估：An Innovative Approach to Gain Confidence in Therapeutic Discovery

In this webinar Josh Apgar, PhD discusses Early Feasibility Assessment (EFA), a quantitative approach to early…

Renee Fisher2024 年 10 月 29 日

Publication

ISB 2001 三特异性 T 细胞衔接器显示出强大的肿瘤细胞毒性，并克服多发性骨髓瘤细胞的免疫逃逸机制

Abstract Despite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma eventually…

Renee Fisher2024 年 9 月 18 日

Publication

构建抗体-药物偶联物（ADCs）从临床前到临床转化的平台定量系统药理学（QSP）模型

Abstract A next generation multiscale quantitative systems pharmacology (QSP) model for antibody drug conjugates (ADCs)…

Renee Fisher2024 年 9 月 18 日

Publication

T 细胞衔接器从体外到临床转化的下一代数学模型

Abstract T-cell engager (TCE) molecules activate the immune system and direct it to kill tumor…

Renee Fisher2024 年 9 月 18 日

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Renee Fisher

引导分子胶降解剂（Molecular Glue Degrader）的目标和先导优化

通过机制建模捕捉 CAR-T 细胞疗法的动态变化

数学模型有助于扩大免疫肿瘤药物治疗自身免疫疾病的应用范围

Mathematical Modeling and the Monkey King: Use of Modeling for More Efficient NHP Study Design

Quantitative systems pharmacology model of GITR-mediated T cell dynamics in tumor microenvironment

早期可行性评估：准确预测生物治疗剂量的方法，为早期药物研发决策提供依据

早期可行性评估：An Innovative Approach to Gain Confidence in Therapeutic Discovery

ISB 2001 三特异性 T 细胞衔接器显示出强大的肿瘤细胞毒性，并克服多发性骨髓瘤细胞的免疫逃逸机制

构建抗体-药物偶联物（ADCs）从临床前到临床转化的平台定量系统药理学（QSP）模型

T 细胞衔接器从体外到临床转化的下一代数学模型

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