Radiometric Analysis
One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…
Nathan Teuscher2014 年 7 月 29 日
FDA JumpStart: an introduction
Discover FDA JumpStart, a ground-breaking service accelerating drug reviews by enhancing data quality, identifying risks,…
Certara2014 年 7 月 16 日
Understanding LC/MS/MS
The most common bioanalytical method in use today is LC/MS/MS, or liquid chromatography (LC) tandem…
Certara2014 年 7 月 15 日
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
Danielle Pillsbury2014 年 7 月 14 日
Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model
Compared to small chemical molecules, antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behavior characterized by…
Danielle Pillsbury2014 年 7 月 9 日
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin
Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…
Danielle Pillsbury2014 年 7 月 9 日
What is HPLC/UV?
In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…
Nathan Teuscher2014 年 7 月 8 日
Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes
Correlation of the thickness of the left ventricular posterior wall (LVPWd) with various parameters, including…
Danielle Pillsbury2014 年 7 月 1 日
A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data
Current cytochrome P450 (CYP) 1A2 and 3A4 ontogeny profiles, which are derived mainly from in…
Danielle Pillsbury2014 年 7 月 1 日
