How Can PK/PD Analysis Add Value to Patient Care?
In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New…
Certara2011 年 7 月 11 日
What is Curve Stripping?
The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…
Certara2011 年 7 月 6 日
Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis
The purpose of this study was to develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to…
Certara2011 年 7 月 1 日
Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model
Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…
Certara2011 年 7 月 1 日
Simulation of Clinical Drug-drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs
Rifampin and carbamazepine have been recommended in the U.S. Food and Drug Administration draft drug…
Certara2011 年 7 月 1 日
Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration
Polycyclic aromatic hydrocarbons (PAHs) are believed to be among the causative agents for lung cancer…
Certara2011 年 7 月 1 日
